P4, Ralf-Peter Jansen
Localized translation of proteins
at the mitochondrial outer membrane
The conventional model of mitochondrial import comprises translation of nuclear-encoded mitochondrial proteins in the cytosol before translocation across the mitochondrial outer membrane (MOM). Recent observations indicate that translation of proteins can also occur near or at the MOM, and is preceded by targeting of the encoding mRNAs to this location. However, the proteins required for this targeting or its regulation are largely unknown, especially in mammalian cells.
In this project, we will apply proximity labeling (BioID) to identify MOM proteins that bind specific mitochondrial–targeted mRNAs.
